RE2 Treatment Pool Room Safe Code and How to Unlock It

9 September 2026 | 52

Navigating the murky sewers in Resident Evil 2 Remake forces players to manage limited ammunition while searching for vital survival gear. One of the most important resource caches hidden within the sewer complex is the locked safe located in the Treatment Pool Room. Cracking this safe provides a valuable weapon upgrade that significantly improves combat performance against the hazardous creatures lurking in the area.

Locating the Safe in the Treatment Pool Room

The Treatment Pool Room safe is situated on the middle level of the sewer system near the footbridge. Players will find it sitting on a desk right beside a cable car platform area. Spotting the safe is relatively easy, but opening it requires finding the combination written elsewhere in the sewers.

Where to Find the Treatment Pool Room Safe Combination

The combination for this safe is written directly on the side of a yellow chalked frame located in the Cable Car Control room. Players can reach this clue while exploring the upper levels of the sewers after obtaining the necessary key items. Inspecting the surrounding walls carefully ensures you do not miss this crucial piece of information.

The Correct Code and Dial Instructions

To unlock the Treatment Pool Room safe, rotate the dial Left to 2, Right to 12, and then Left to 8. You must pause slightly on each number before entering the next direction for the mechanism to register correctly. Once the final number is aligned, confirm the input to pop open the heavy steel door.

Rewards Inside the Safe for Leon and Claire

The reward inside the safe varies depending on which protagonist you are currently playing as during your campaign run. Leon receives the Shotgun Stock for his W-870, which drastically reduces recoil and increases rate of fire. Meanwhile, Claire obtains a High-Capacity Mag for her SLS 60 handgun, granting faster reload times and expanded ammo capacity.

Tactical Tips for Exploring the Sewer Area

Unlocking weapon parts early in the sewers makes subsequent encounters with G-Adults and zombie hordes far more manageable. Always clear nearby enemies before standing at the safe to prevent taking unexpected damage while dialing. Securing these upgrades gives players a noticeable tactical advantage before stepping into the final laboratory section of the game.